A copper-containing enzyme, 1,4-benzenediol oxidase (EC 1.10.3.2), found in higher plants and microorganisms. Laccases are multicopper oxidases of wide specificity that carry out one-electron oxidation of phenolic and related compounds, and reduce O2 to water. The enzymes are polymeric and generally contain one each of type 1, type 2, type 3 copper centers per subunit, where the type 2 and type 3 are close together forming a trinuclear copper cluster.