Proteins in which non-heme iron is coordinated with cysteine sulfur and usually also with inorganic sulfur. Divided into three major categories: rubredoxins; "simple iron-sulfur proteins", containing only iron-sulfur clusters, and "complex iron-sulfur proteins", containing additional active redox centers such as flavin, molybdenum or heme. In most iron-sulfur proteins the clusters function as electron transfer groups, but in others they have other functions such as catalysis of hydratase/dehydratase reactions, maintenance of protein structure, or regulation of activity.
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