protein folding

[Zami'87]

I have some questions about chaperonins and protein folding...
1.How do chaperonins help folding the polypeptide chain(know about hydrogen bonds but mechanism...)? like enzyme?What's their origin? And did "first cell" contain genes for them?What if there would be a mutation and and some chaperonin would be nonfunctional? Would it be lethal?
How do polypeptide chains form protein with quaternary structure(are there also some helpers -exept chap.)?
Maybe sounded stupid but you can easily lost in details :oops:
Thanks in advance!