amide
 

can any one help me out to find out the correct solvent system for amide detection by thin layer chromatography ....thanx

As far as I know, there's no hard and fast rule for what solvent system to use. On a general level though, these are things to keep in mind:

Amides are pretty polar molecules. TLC is generally coated with a polar stationary phase. You'll want something kinda polar but not extremely polar I'd guess...maybe an ether or ester?

As far as I know, there's no hard and fast rule for what solvent system to use. On a general level though, these are things to keep in mind:

Amides are pretty polar molecules. TLC is generally coated with a polar stationary phase. You'll want something kinda polar but not extremely polar I'd guess...maybe an ether or ester?

Depending on what kind of other functional groups you have on the molecule there are a couple of ways you may be able to TLC this compound. First try I would use 95% CH2Cl2/5% MeOH with 1% NH3 added (you can add NH4OH). If this doesn't move it off the baseline then up the amount of MeOH/NH3 up to 10%. If this fails you can try to use a water/acetonitrile mix on silica TLC plates. If you can get your hands on C18 plates use those for the water/acetonitrile systems.